Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment.

IF 6.5 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY International Journal of Nanomedicine Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S504629

Yunheng Liu, Longqing Si, Yuxuan Jiang, Shaojing Jiang, Xiaokang Zhang, Song Li, Jing Chen, Jinghui Hu

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Abstract

The metabolic activity of tumor cells leads to the acidification of the surrounding microenvironment, which provides new strategies for the application of nanotechnology in cancer therapy. Researchers have developed various types of pH-responsive nanomaterials based on the tumor acidic microenvironment. This review provides an in-depth discussion on the design mechanisms, drug-loading strategies, and application pathways of tumor acidic microenvironment-responsive nanodrug delivery systems. These materials trigger drug release upon reaching the tumor microenvironment, enhancing therapeutic targeting and reducing toxicity to healthy cells. pH-responsive nanomaterials include organic nanomaterials, inorganic nanomaterials, and composite nanomaterials. Additionally, this review outlines the drug-loading strategies, application prospects, and challenges of pH-responsive nanomaterials, aiming to promote the development and clinical translation of this field.

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基于肿瘤微环境的ph响应纳米材料设计

肿瘤细胞的代谢活性导致了周围微环境的酸化，这为纳米技术在癌症治疗中的应用提供了新的策略。研究人员基于肿瘤酸性微环境开发了各种类型的ph响应纳米材料。本文就肿瘤酸性微环境反应性纳米给药系统的设计机制、载药策略和应用途径等方面进行了综述。这些物质在到达肿瘤微环境时触发药物释放，增强治疗靶向性并降低对健康细胞的毒性。ph响应纳米材料包括有机纳米材料、无机纳米材料和复合纳米材料。此外，本文综述了ph响应纳米材料的载药策略、应用前景和面临的挑战，旨在促进该领域的发展和临床转化。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.