ABCB1 Polymorphism Is Associated with Higher Carbamazepine Clearance in Children.

IF 1.4 Q3 PEDIATRICS Pediatric Reports Pub Date : 2025-01-16 DOI:10.3390/pediatric17010010

Natasa Djordjevic, Jelena Cukic, Dragana Dragas Milovanovic, Marija Radovanovic, Ivan Radosavljevic, Jelena Vuckovic Filipovic, Slobodan Obradovic, Dejan Baskic, Jasmina R Milovanovic, Slobodan Jankovic, Dragan Milovanovic

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Abstract

The aim of our study was to investigate the role of ABCB1 polymorphism in the pharmacokinetics of carbamazepine (CBZ) in children. The study enrolled 47 Serbian pediatric epileptic patients on CBZ treatment. Genotyping for ABCB1 1236CABCB1 1236CABCB1 + 0.0176 × CYP1A2 + 0.000151 × DD where SEX has a value of 1 if male and 0 if female, ABCB1 has a value of 1 if C-G-C/T-T-T and 0 if any other ABCB1 diplotype, CYP1A2 has a value of 1 if -163A/A and 0 if -163C/C or C/A, and DD is the total CBZ daily dose (mg/day). The presence of the ABCB1 1236T-2677T-3435T haplotype is associated with an increased clearance of CBZ in pediatric epileptic patients.

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ABCB1多态性与儿童较高的卡马西平清除率相关

本研究的目的是探讨ABCB1多态性在卡马西平（CBZ）儿童药代动力学中的作用。该研究招募了47名接受CBZ治疗的塞尔维亚儿童癫痫患者。ABCB1 1236CABCB1 1236CABCB1 + 0.0176 × CYP1A2 + 0.000151 × DD的基因分型，其中SEX值为男性为1，女性为0，ABCB1值为C- g -C/T-T-T为1，其他ABCB1二倍型为0，CYP1A2值为-163A/ a为1，-163C/C或C/ a为0，DD为总CBZ日剂量（mg/天）。ABCB1 1236T-2677T-3435T单倍型的存在与儿童癫痫患者CBZ清除率增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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