Arturo Gonzales-Rodriguez , Juan Carlos Gómez-de-la-Torre , Luis Alvarado , Edgar Gonzales Escalante
{"title":"First report of KPC-35-producing Klebsiella pneumoniae ST258 isolated in Peru","authors":"Arturo Gonzales-Rodriguez , Juan Carlos Gómez-de-la-Torre , Luis Alvarado , Edgar Gonzales Escalante","doi":"10.1016/j.ram.2024.10.008","DOIUrl":null,"url":null,"abstract":"<div><div><em>Klebsiella pneumoniae</em> sequence type 258 (ST258) is the main cause of the global spread of KPC and a significant public health problem. In 2015, ceftazidime/avibactam (CZA) was introduced as a therapeutic alternative and since it has contributed to the development of new KPC variants. Here we present the identification of two consecutive isolations of <em>K. pneumoniae</em> ST258 (KP1 and KP2), from a patient with urinary tract infection. KP1 and KP2 harbored <em>bla</em><sub>KPC-2</sub> and <em>bla</em><sub>KPC-35</sub>, respectively. KP2 exhibited a modified susceptibility profile to carbapenems and resistance to CZA. To the best of our knowledge, this is the first report of <em>K. pneumoniae</em> ST258 in Peru, which highlights the increasing problem of CZA resistance.</div></div>","PeriodicalId":21163,"journal":{"name":"Revista Argentina de microbiologia","volume":"57 1","pages":"Pages 3-7"},"PeriodicalIF":2.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Argentina de microbiologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0325754124001299","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/22 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Klebsiella pneumoniae sequence type 258 (ST258) is the main cause of the global spread of KPC and a significant public health problem. In 2015, ceftazidime/avibactam (CZA) was introduced as a therapeutic alternative and since it has contributed to the development of new KPC variants. Here we present the identification of two consecutive isolations of K. pneumoniae ST258 (KP1 and KP2), from a patient with urinary tract infection. KP1 and KP2 harbored blaKPC-2 and blaKPC-35, respectively. KP2 exhibited a modified susceptibility profile to carbapenems and resistance to CZA. To the best of our knowledge, this is the first report of K. pneumoniae ST258 in Peru, which highlights the increasing problem of CZA resistance.
期刊介绍：
La Revista Argentina de Microbiología es una publicación trimestral editada por la Asociación Argentina de Microbiología y destinada a la difusión de trabajos científicos en las distintas áreas de la Microbiología. La Asociación Argentina de Microbiología se reserva los derechos de propiedad y reproducción del material aceptado y publicado.
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