Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.

IF 4.7 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2025-01-24 DOI:10.1186/s13619-025-00221-5
Jimpi Langthasa, Li Guan, Shyam Lal Jinagal, Quynh-Thu Le
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Abstract

Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren's syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.

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唾液腺干/祖细胞:从基础科学到临床应用的进展。
唾液腺干/祖细胞(SSPCs)在再生医学中具有巨大的潜力,特别是对于因放射治疗、Sjögren综合征和衰老等各种原因而患有唾液腺功能障碍的患者。本文综述了SSPCs的特点、分离、培养技术、分化途径及其在组织再生中的作用。此外,我们重点介绍了细胞和组织为基础的治疗方法的最新进展,如SSPC移植和生物工程器官替代。本文还讨论了将SSPC研究转化为有效临床治疗的挑战,以及提出的解决方案和未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
期刊最新文献
HUMSCs repair CCl₄-induced chronic liver injury in rats via metabolic regulation. ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease. Lgr5⁺ cells regulate small intestinal morphogenesis before villification. FRZB regulates the osteogenic differentiation of periodontal ligament stem cells in an inflammatory microenvironment through Wnt5a-mitochondrial axis. MRG15 decline in aged/injured MuSCs hinders regeneration via differentiation defects.
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