Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2025-01-24 DOI:10.1186/s13619-025-00221-5
Jimpi Langthasa, Li Guan, Shyam Lal Jinagal, Quynh-Thu Le
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引用次数: 0

Abstract

Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren's syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.

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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
期刊最新文献
Neural stem cell heterogeneity in adult hippocampus. Prmt5 is essential for intestinal stem cell maintenance and homeostasis. Salivary gland stem/progenitor cells: advancing from basic science to clinical applications. Saponins enhance the stability and cost-efficiency of human embryonic stem cell culture. Standard: Human gastric organoids.
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