HYDROGEN SULFIDE AND CYSTATHIONINE γ-LYASE LEVELS FOR PATIENTS WITH PARKINSON'S DISEASE.

Abstract

Parkinson's disease (PD) is a complicated neurodegenerative disease that is the most prevalent severe movement disorder worldwide. The research includes studying the levels of hydrogen sulphide (H2S) and cystathionine γ-lyase (CSE) with some biochemical parameters in the serum of patients with PD in Mosul City (Iraq), which include Serotonin (SERT), dopamine (DA), sphingomyelin (SM), vitamin B12, Acetylcholine esterase (AChE), monoamine oxidase (MAO), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT). Samples reached (100), which included: (40) for the Parkinson's patients group, and (60) for the control group. The results showed there was a significant decrease in the levels of H2S, CSE, SERT, DA, SM, B12 and CK and a significant increase in the activity of MAO, AST, and ALT and no significant difference in AChE activity in serum for Parkinson's patients when compared with the control group. The effect of periods PD revealed, a significant decline of H2S, CSE, SERT, DA, B12, and AChE, while MAO, CK, AST, and ALT showed a significant rise with increased periods of disease, SM showed a non-significant change with periods of disease. The study concluded that H2S gas produced within the body and CSE suffer from low levels within the body, and they also decrease with the increase in the duration of the disease as a result of their use as protective functions in the body against Parkinson's disease. And developing it by observing the levels of the variables measured with it, and stimulating the body to increase their levels (H2S, CSE) in various ways can lead to improving the health condition of patients.