Asperhydrindane A, a new hydrindane derivate isolated from a mangrove-derived fungi Aspergillus terreus GXIMD 03158

IF 1.6 3区 化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2026-04-18 Epub Date: 2025-01-20 DOI:10.1080/14786419.2025.2456670
Yue Jiang , Fan An , Yu-Man Gan , Kai Liu , Yong-Hong Liu , Cheng-Hai Gao , Pei Cao , Xiang-Xi Yi , Meng Bai
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Abstract

A new hydrindane derivative, asperhydrindane A (1), along with two known sterol analogues [isocyathisterol (2) and ganodermasides D (3)] were isolated from the mangrove-derived fungus Aspergillus terreus GXIMD 03158 attaching to the mangrove Acanthus ilicifoius L. The structure of 1 was elucidated based on extensive spectral analysis, HRESIMS, and calculated ECD methods. All compounds were evaluated for antibacterial activity. The result showed that only compound 3 exhibited significant antibacterial activity against Staphylococcus aureus, Vibrio harveyi, and Vibrio parahaemolyticus with MIC values of 6.25, 3.12, and 1.56 μg/mL, respectively.
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从一种源自红树林的真菌土曲霉GXIMD 03158中分离得到一个新的黑丹衍生物——黑丹A。
从附着在红树林Acanthus ilicifoius L.上的红树衍生真菌Aspergillus terreus GXIMD 03158中分离出一种新的水杨丹衍生物asperhydrindane A(1),以及两种已知的甾醇类似物[isocyathisterol(2)和ganodermasides D(3)]。对所有化合物进行抗菌活性评价。结果表明,只有化合物3对金黄色葡萄球菌、哈维弧菌和副溶血性弧菌具有显著的抑菌活性,其MIC值分别为6.25、3.12和1.56 μg/mL。
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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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