Impact of environmentally relevant concentrations of glyphosate on Boana faber tadpoles exposed in the laboratory: Morphological and functional markers

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-22 DOI:10.1016/j.etap.2025.104643

Cristiano Roberto Hentges , Laura Kauer Schuck , Carolina De Abreu Caberlon , Alexandro Marques Tozetti , Guendalina Turcato Oliveira

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Abstract

This study evaluated the effects of a glyphosate-based herbicide on the oxidative balance, energy metabolism, and body condition indices in tadpoles of Boana faber. Anuran spawns were collected, and after hatching and reaching Gosner stage 25, they were acclimated and exposed (168 hours) to concentrations of glyphosate (G1: 65, G2: 260, and G3: 520 µg/L). The body condition markers revealed a significant decrease in all these biomarkers in G2 and G3. Tadpoles exposed to the highest concentration of glyphosate showed an increase in superoxide dismutase activity and the maintenance of lipoperoxidation levels. Carbonyl proteins of animals of G1 and G2 groups showed a reduction that coincides with increased catalase activity. Glycogen decreased in all exposed groups, indicating that this polysaccharide was used for energy production. The body condition markers established here are a non-invasive and promising way of assessing the health status of animals.

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环境相关浓度草甘膦对实验室暴露的Boana faber蝌蚪的影响：形态和功能标记。

本研究评价了草甘膦类除草剂对白桦小蝌蚪氧化平衡、能量代谢和身体状况指标的影响。收集Anuran卵，在孵化并达到Gosner期25后，将其驯化并暴露于草甘膦浓度（G1: 65， G2: 260和G3: 520µg/L）中（168小时）。G2和G3组的身体状况指标均明显下降。暴露于最高浓度草甘膦的蝌蚪表现出超氧化物歧化酶活性的增加和脂质过氧化水平的维持。G1和G2组动物羰基蛋白的减少与过氧化氢酶活性的增加一致。糖原在所有暴露组中均下降，表明这种多糖被用于能量生产。这里建立的身体状况标记是一种非侵入性和有前途的评估动物健康状况的方法。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.