99mTc radiolabeling of palm shell charcoal: A preliminary study for potential lung ventilation scintigraphy agent

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Applied Radiation and Isotopes Pub Date : 2025-04-01 Epub Date: 2025-01-19 DOI:10.1016/j.apradiso.2025.111689

I. Saptiama , M. Munir , I.S. Qaira , F. Rindiyantono , A. Nurmanjaya , K.E. Prasetya , M. Subechi , Marlina , Abidin , G. Suhariyono , Ferry , K.S.S. Putri , A.S. Wismogroho , C. Firdharini

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Abstract

To investigate the potential of activated carbon from palm kernel shell waste for ^99mTc-radiolabeled nanocarbon aerosol, a new production technology for carbon-based ^99mTc-radioaerosol from such a waste was developed. Treated-palm shell charcoal (t-PSC) was prepared by hydrothermal method to increase the surface area, followed by ^99mTc radiolabelling optimization. The optimal ^99mTc radiolabeling conditions resulted in an adsorption capacity of 21.43 ng Re/g t-PSC (8.32 GBq ^99mTc/g t-PSC). After high-energy milling treatment, fines particle fraction (FPF), and median mass aerodynamic diameter (MMAD) of the milled t-PSC were 28.34 ± 0.61%, and 8.31 ± 2.31 μm, respectively. The results imply that ^99mTc-labeled t-PSC has a potential for lung ventilation scan agents with the optimization of milling process to reduce the aerodynamic size within the optimal lung delivery of less than 5 μm.

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棕榈壳炭的99mTc放射性标记：潜在肺通气显像剂的初步研究。

为研究利用棕榈仁壳废弃物活性炭制备99mtc放射性标记纳米碳气溶胶的潜力，开发了一种利用棕榈仁壳废弃物制备碳基99mtc放射性气溶胶的新工艺。采用水热法制备经处理的棕榈壳炭（t-PSC），增加其表面积，并对其进行99mTc放射性标记优化。99mTc放射性标记的最佳条件为吸附量21.43 ng Re/g t-PSC （8.32 GBq 99mTc/g t-PSC）。经高能铣削处理后的t-PSC的细粒分数（FPF）和中位质量气动直径（MMAD）分别为28.34±0.61%和8.31±2.31 μm。结果表明，99mtc标记的t-PSC具有作为肺部通气扫描剂的潜力，通过优化铣削工艺，将气动尺寸减小到最佳肺输送尺寸小于5 μm。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.