Jun-Lei Zhang, Xin-Lan Zhao, You-Zhi Liao, Yi Zhao, Fei Pan
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引用次数: 0
Abstract
A novel Ru-catalyzed radical-triggered trifunctionalization of hexenenitriles is presented, employing a strategy of remote cyano group migration and meta-C(sp2)–H functionalization. Through remote cyano migration, the alkenyl moiety undergoes difunctionalization to the formation of a benzylic radical intermediate. This intermediate facilitates para-selective C–H bond addition relative to the C–Ru bond within the Ru(III) complex, ultimately enabling trifunctionalization. This methodology provides an efficient route to a diverse array of nitrile-containing compounds with broad functional group compatibility.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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