{"title":"A new diterpenoid, carneadiol, isolated from Nocardia carnea IFM 12324","authors":"Yasumasa Hara, Ayaka Nakamura, Teruhisa Manome, Akiko Takaya, Hiroki Takahashi, Sayaka Ban, Takashi Yaguchi, Masami Ishibashi","doi":"10.1007/s11418-025-01878-7","DOIUrl":null,"url":null,"abstract":"<div><p>A new diterpenoid, carneadiol (<b>1</b>), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts of <i>Nocardia carnea</i> IFM 12324. The structure of compound <b>1</b> was elucidated using spectral studies, including various NMR data. The absolute configuration of <b>1</b> was determined using X-ray crystallographic analysis with the crystalline sponge method. The biosynthetic gene of compound <b>1</b> was deduced, and it was observed that the mRNA of the gene involved in terpenoid cyclization increased significantly in the strain producing compound <b>1</b>.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 2","pages":"435 - 440"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11418-025-01878-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts of Nocardia carnea IFM 12324. The structure of compound 1 was elucidated using spectral studies, including various NMR data. The absolute configuration of 1 was determined using X-ray crystallographic analysis with the crystalline sponge method. The biosynthetic gene of compound 1 was deduced, and it was observed that the mRNA of the gene involved in terpenoid cyclization increased significantly in the strain producing compound 1.
期刊介绍：
The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers:
-chemistry of natural products
-biochemistry of medicinal plants
-pharmacology of natural products and herbs, including Kampo formulas and traditional herbs
-botanical anatomy
-cultivation of medicinal plants.
The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
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