Therapeutic strategies targeting CD47-SIRPα signaling pathway in gastrointestinal cancers treatment.

Journal of pharmaceutical analysis Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI:10.1016/j.jpha.2024.101099
Zhengping Che, Wei Wang, Lin Zhang, Zhenghong Lin
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Abstract

Gastrointestinal (GI) cancers are prevalent globally, with leading incidence and mortality rates among malignant tumors. Despite notable advancements in surgical resection, radiotherapy, and chemotherapy, the overall survival rates remain low. Hence, it is imperative to explore alternative approaches that enhance patient outcomes. Cluster of differentiation 47 (CD47), serving as an early diagnostic marker, is predominantly overexpressed in GI cancers and associated with poor prognosis. Targeting the CD47-signal regulatory protein alpha (SIRPα) signaling pathway may provide a novel strategy for GI cancers treatment. This study summarizes current knowledge of the structure and function of CD47 and SIRPα, their roles in signaling pathways, the prognostic significance of CD47, therapeutic strategies targeting the CD47-SIRPα signaling pathway in GI cancer, and highlights key issues for future investigations.

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胃肠道(GI)癌症在全球范围内普遍存在,其发病率和死亡率在恶性肿瘤中均居首位。尽管在手术切除、放疗和化疗方面取得了显著进展,但总体生存率仍然很低。因此,当务之急是探索能提高患者预后的替代方法。作为早期诊断标志物的分化簇 47(CD47)主要在消化道癌症中过表达,并与不良预后相关。靶向 CD47-信号调节蛋白α(SIRPα)信号通路可为消化道癌症治疗提供一种新策略。本研究总结了目前关于CD47和SIRPα的结构和功能、它们在信号通路中的作用、CD47对预后的意义、针对消化道癌症CD47-SIRPα信号通路的治疗策略的知识,并强调了未来研究的关键问题。
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