Current Role of MicroRNAs in the Diagnosis and Clinical Management of Germ Cell Tumors

Q1 Medicine Surgical Pathology Clinics Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI:10.1016/j.path.2024.08.003

Nuno Tiago Tavares MSc , Rui Henrique MD , Carmen Jerónimo BSc, MSc, PhD , João Lobo MD, PhD

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microrna在生殖细胞肿瘤诊断和临床治疗中的作用。

生殖细胞肿瘤（gct）是一种罕见且异质性的肿瘤，起源于原始生殖细胞。MicroRNAs是一种小的非编码rna，在过去十年中作为潜在的癌症生物标志物出现。特别是，在几个成熟的队列中，miR-371a-3p在原位来源的睾丸gct中显示出良好的生殖细胞瘤诊断性能，并有望在不久的将来进入临床领域。gct普遍表现出miR-371-373和miR-302/367簇的高表达和let-7家族mirna的低表达。需要进一步的研究来评估这些mirna作为卵巢和卵巢外gct的生物标志物的潜在作用。

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来源期刊

Surgical Pathology Clinics Medicine-Surgery

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4.40

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0.00%

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期刊介绍： This newest addition to the Clinics Series keeps you current on the information that is essential to every practicing surgical pathologist, from the latest techniques and approaches to detailed discussions on differential diagnosis. It devotes each and every issue exclusively to surgical pathology and its associated problems and is enhanced by abundant full-color images. Each issue focuses on a single topic-and is overseen by Guest Editors who are experts in their field-providing information of practical value on service while also offering material that increases understanding.

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