Exploring Menatetrenone: Origin, Chemistry, Therapies and Delivery.

IF 2.6 4区医学 Q1 NUTRITION & DIETETICS Journal of the American Nutrition Association Pub Date : 2025-08-01 Epub Date: 2025-02-03 DOI:10.1080/27697061.2025.2460539

Widhilika Singh, Poonam Kushwaha, Shom Prakash Kushwaha

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Abstract

Menatetrenone (MK-4), a potent form of vitamin K2, has gained significant attention for its diverse therapeutic potential, particularly in bone health, cardiovascular protection, and metabolic disorders. This manuscript explores the origins and chemical structure of menatetrenone, highlighting its synthesis from dietary sources and its enzymatic conversion in the body. The review examines the extensive therapeutic applications of MK-4, focusing on its role in treating osteoporosis, diabetes, and cardiovascular diseases, along with emerging evidence of its anticancer and neuroprotective effects. Furthermore, the manuscript discusses innovative delivery systems, such as nanostructured lipid carriers and other advanced formulations, designed to enhance the bioavailability and therapeutic efficacy of menatetrenone. By addressing the challenges associated with its pharmacokinetics and exploring novel drug delivery strategies, this review provides a comprehensive overview of menatetrenone's therapeutic promise and outlines future directions for its clinical use.

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探索美萘特酮：起源，化学，治疗和递送。

美萘特孕酮（MK-4）是维生素K2的一种有效形式，因其多种治疗潜力而受到广泛关注，特别是在骨骼健康、心血管保护和代谢紊乱方面。本文探讨了美萘特酮的起源和化学结构，重点介绍了其从膳食来源合成及其在体内的酶转化。本文综述了MK-4的广泛治疗应用，重点关注其在治疗骨质疏松症、糖尿病和心血管疾病中的作用，以及其抗癌和神经保护作用的新证据。此外，手稿讨论了创新的输送系统，如纳米结构脂质载体和其他先进的配方，旨在提高美那曲酮的生物利用度和治疗效果。通过解决与其药代动力学相关的挑战和探索新的药物递送策略，本综述提供了美那曲酮的治疗前景的全面概述，并概述了其临床应用的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the American Nutrition Association

CiteScore

2.50

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0.00%

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