Exploring Menatetrenone: Origin, Chemistry, Therapies and Delivery.

IF 6.8 4区医学 Q1 NUTRITION & DIETETICS Journal of the American Nutrition Association Pub Date : 2025-02-03 DOI:10.1080/27697061.2025.2460539

Widhilika Singh, Poonam Kushwaha, Shom Prakash Kushwaha

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Abstract

Menatetrenone (MK-4), a potent form of vitamin K2, has gained significant attention for its diverse therapeutic potential, particularly in bone health, cardiovascular protection, and metabolic disorders. This manuscript explores the origins and chemical structure of menatetrenone, highlighting its synthesis from dietary sources and its enzymatic conversion in the body. The review examines the extensive therapeutic applications of MK-4, focusing on its role in treating osteoporosis, diabetes, and cardiovascular diseases, along with emerging evidence of its anticancer and neuroprotective effects. Furthermore, the manuscript discusses innovative delivery systems, such as nanostructured lipid carriers and other advanced formulations, designed to enhance the bioavailability and therapeutic efficacy of menatetrenone. By addressing the challenges associated with its pharmacokinetics and exploring novel drug delivery strategies, this review provides a comprehensive overview of menatetrenone's therapeutic promise and outlines future directions for its clinical use.

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