{"title":"Liposomes: Bridging the gap from lab to pharmaceuticals","authors":"Remo Eugster, Paola Luciani","doi":"10.1016/j.cocis.2024.101875","DOIUrl":null,"url":null,"abstract":"<div><div>Liposomes are versatile and effective drug delivery systems, as highlighted by various medical applications. Their well-defined bilayer structure is suited for the encapsulation of drugs with diverse chemical properties and for a variety of release strategies. Understanding liposome self-assembly and structure is crucial for enhancing drug development and delivery efficiency. Herein, we review the self-assembly process of liposomes and transfer this knowledge to means of production. The challenges and opportunities of scaling liposomal production are discussed. Key techniques, to characterize the particles, their interface and composition, essential for market approval, are outlined. Views on novel computational methods to deepen the lipid behavior at interfaces and accelerate liposome development are given, including opinions on using artificial intelligence to support liposome production.</div></div>","PeriodicalId":293,"journal":{"name":"Current Opinion in Colloid & Interface Science","volume":"75 ","pages":"Article 101875"},"PeriodicalIF":7.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Colloid & Interface Science","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359029424000931","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Liposomes are versatile and effective drug delivery systems, as highlighted by various medical applications. Their well-defined bilayer structure is suited for the encapsulation of drugs with diverse chemical properties and for a variety of release strategies. Understanding liposome self-assembly and structure is crucial for enhancing drug development and delivery efficiency. Herein, we review the self-assembly process of liposomes and transfer this knowledge to means of production. The challenges and opportunities of scaling liposomal production are discussed. Key techniques, to characterize the particles, their interface and composition, essential for market approval, are outlined. Views on novel computational methods to deepen the lipid behavior at interfaces and accelerate liposome development are given, including opinions on using artificial intelligence to support liposome production.
期刊介绍：
Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications.
Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments.
Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
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