Peculiarities of General and Mucosal Immunity in Urban Residents of Murmansk Oblast

Abstract

The state of general and mucosal immunity was studied in 103 permanently living and working residents of Apatity town, Murmansk oblast. In examined individuals, a high level of deficiency of active neutrophilic phagocytes in the peripheral blood and on mucous membranes of the pharynx, urinary system, and intestine is established. A high frequency of registration of a deficiency of the sorption capacity of epitheliocytes and levels of secretory immunoglobulins A are detected. An increase in the concentration of pathogenic microorganisms on mucous membranes of the pharynx and urinary system and a deficiency of normal microflora on mucous membranes of the intestine are observed. Long life in unfavorable climate conditions is characterized by a high level of deficiency of mature T lymphocytes, T helpers, and T lymphocytes with a transferrin receptor and cells to programmed cell death.