{"title":"Simple and efficient synthesis of novel thiazolo[4,5-e]indole derivatives via three-component reaction","authors":"Bing-Wei Wang, Ming-Han Huang, Xue Wang, Dong-Sheng Chen","doi":"10.1007/s12039-024-02345-8","DOIUrl":null,"url":null,"abstract":"<div><p>A series of thiazolo[4,5-<i>e</i>]indole derivatives have been obtained by a three-component domino reaction of 2-methylbenzo[<i>d</i>]thiazol-5-amine, arylglyoxal monohydrates and cyclohexane-1,3-dione in ethanol medium at 80°C catalyzed by acetic acid. Notable features of this synthesis are mild reaction, high synthesis efficiency, simple post-treatment operation and only water is generated as a byproduct.</p><h3>Graphical abstract</h3><p>\nA new procedure for the synthesis of thiazolo[4,5-<i>e</i>]indole derivatives.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Sciences","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s12039-024-02345-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A series of thiazolo[4,5-e]indole derivatives have been obtained by a three-component domino reaction of 2-methylbenzo[d]thiazol-5-amine, arylglyoxal monohydrates and cyclohexane-1,3-dione in ethanol medium at 80°C catalyzed by acetic acid. Notable features of this synthesis are mild reaction, high synthesis efficiency, simple post-treatment operation and only water is generated as a byproduct.
Graphical abstract
A new procedure for the synthesis of thiazolo[4,5-e]indole derivatives.
期刊介绍：
Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.
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