{"title":"The Key of the Terminal Stage of Vitiligo: The Death Form of Melanocytes","authors":"Chen Zhang, YuXing Gao, Wei Yan, XiaoYong Yuan, MengYang Wei, Yue Shen","doi":"10.1155/dth/1133166","DOIUrl":null,"url":null,"abstract":"<div>\n <p>Vitiligo is a complex skin disease with multiple genes and multiple targets. Its etiology is complex, and the final link is the death or dysfunction of melanocytes. Melanocytes are derived from neural crest cells, and their mechanism of death is complex. Currently, more studies have focused on apoptosis, necrosis, ferroptosis, and autophagy. Aiming to reveal the key to the terminal stage of vitiligo: the death form of melanocytes, we summarize the origin, differentiation, and migration of melanocytes, analyze the ontogenetic and morphological characteristics of melanocytes and various death forms of melanocytes, and discuss their corresponding mechanism in this reviews.</p>\n </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/1133166","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologic Therapy","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/dth/1133166","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vitiligo is a complex skin disease with multiple genes and multiple targets. Its etiology is complex, and the final link is the death or dysfunction of melanocytes. Melanocytes are derived from neural crest cells, and their mechanism of death is complex. Currently, more studies have focused on apoptosis, necrosis, ferroptosis, and autophagy. Aiming to reveal the key to the terminal stage of vitiligo: the death form of melanocytes, we summarize the origin, differentiation, and migration of melanocytes, analyze the ontogenetic and morphological characteristics of melanocytes and various death forms of melanocytes, and discuss their corresponding mechanism in this reviews.
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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