{"title":"Resensitizing β-Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment (Adv. Sci. 5/2025)","authors":"Tingwang Shi, Qiong Wu, Zesong Ruan, Zhiyuan Luo, Wenbo Wang, Zhao Guo, Yihong Ma, Xin Wang, Guangyu Chu, Han Lin, Min Ge, Yunfeng Chen","doi":"10.1002/advs.202570025","DOIUrl":null,"url":null,"abstract":"<p><b>Small Colony Variant</b></p><p>The phenotypic instability of small colony variants (SCVs) complicates investigating their role in osteomyelitis. Min Ge, Yunfeng Chen, and co-workers clarified the pathogenic mechanism of clinically isolated SCVs with <i>hpt</i> mutations and proposed a nanomedicine system for co-delivering antibiotics to treat SCV-associated osteomyelitis. More details are available in article number 202410781.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 5","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570025","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570025","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Small Colony Variant
The phenotypic instability of small colony variants (SCVs) complicates investigating their role in osteomyelitis. Min Ge, Yunfeng Chen, and co-workers clarified the pathogenic mechanism of clinically isolated SCVs with hpt mutations and proposed a nanomedicine system for co-delivering antibiotics to treat SCV-associated osteomyelitis. More details are available in article number 202410781.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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