Front Cover: Protein Engineering of Lipase A from Candida Antarctica to Improve Esterification of Tertiary Alcohols (ChemBioChem 24/2024)

Abstract

The front cover shows the structure of lipase A from Candida antarctica with auroras in the background. Like this light display of Nature in the sky, enzymes sometimes unfold their power in unexpected forms, thus enriching the scope of applications. By engineering the active site, the catalytic properties of the lipase can be further improved so that the enzyme begins its infinite journey through space and time typified by the enantioselective esterification of (R)-tertiary alcohols, which has been difficult to achieve. More details can be found in article 10.1002/cbic.202400082 by Shuji Akai, Harald Gröger, and co-workers.