Functions of immunologically active peptides and their roles in intestinal inflammation

IF 6.9 Q1 FOOD SCIENCE & TECHNOLOGY Food frontiers Pub Date : 2024-09-30 DOI:10.1002/fft2.441
Litong Wang, Yi Li, Kunlun Huang, Qin Wang, Xiaoyun He
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Abstract

Immunologically active peptides are a class of peptides with immune functions such as enhancing body immunity, regulating cell growth and differentiation, migration, chemotaxis, neurotransmission, and inducing apoptosis of tumor cells. They have many features, such as small molecular weight, strong stability, high biological activity, easy to adjust the structure accurately, and easy to synthesize. Exploring the mechanism of action of immunologically active peptides can help the modification and development of immunologically active peptides. In this article, the functional properties of immunologically active peptides are described from the perspectives of structural classification of immunologically active peptides and regulatory mechanisms. The relationship between structure and function and the application of different mechanisms in diseases are reviewed, focusing on the role in intestinal inflammation.

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免疫活性肽的功能及其在肠道炎症中的作用
免疫活性肽是一类具有增强机体免疫力、调节细胞生长分化、迁移、趋化、神经传递、诱导肿瘤细胞凋亡等免疫功能的肽。它们具有分子量小、稳定性强、生物活性高、结构易于精确调节、易于合成等特点。探索免疫活性肽的作用机制有助于免疫活性肽的修饰和开发。本文从免疫活性肽的结构分类和调控机制等方面阐述了免疫活性肽的功能特性。本文综述了结构与功能的关系以及不同机制在疾病中的应用,重点介绍了其在肠道炎症中的作用。
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10.50
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审稿时长
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