[Intralesional rituximab for refractory granuloma faciale].

IF 0.7 Dermatologie (Heidelberg, Germany) Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI:10.1007/s00105-025-05476-2
Lea Braun, Christoph Löser, Mindaugas Andrulis, Matthias Uhl, Manfred Wolter, Edgar Dippel
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Abstract

A 60-year-old man presented with refractory granuloma faciale. After unsuccessful treatment with dapsone, hydroxychloroquine, and radiotherapy, treatment with intralesional rituximab was initiated. This led to a steady improvement in the lesions without serious side effects. The case shows that rituximab can be a treatment option for refractory cases of granuloma faciale, especially in the context of IgG 4-related autoimmune disease.

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[病灶内美罗华治疗难治性面部肉芽肿]。
一位60岁男性,因难治性面部肉芽肿就诊。在用氨苯砜、羟氯喹和放疗治疗不成功后,开始用局部利妥昔单抗治疗。这导致病变稳步改善,没有严重的副作用。该病例表明,利妥昔单抗可以作为难治性面部肉芽肿病例的治疗选择,特别是在IgG 4相关自身免疫性疾病的背景下。
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