EUS-based shear wave elastography of the spleen for detection of clinically significant portal hypertension

iGIE Pub Date : 2024-12-01 DOI:10.1016/j.igie.2024.09.002

Jad P. AbiMansour MD , Jerry Yung-Lun Chin MBBS , Eric J. Vargas MD , Jyotroop Kaur MBBS , Barham K. Abu Dayyeh MD, MPH , Ryan J. Law DO , Vishal Garimella MBBS , Michael J. Levy MD , Andrew C. Storm MD , Ross Dierkhising MS , Alina Allen MD , Vinay Chandrasekhara MD

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Abstract

Background and Aims

A measurement of spleen stiffness has been demonstrated to improve the detection of clinically significant portal hypertension (CSPH). In this study, we evaluated the performance of EUS-guided shear wave elastography (EUS-SWE) for detecting CSPH.

Methods

EUS-SWE measurements of the spleen were compared between patients with and without CSPH. Receiver-operating characteristic curve analysis was performed and quantified by the area under the receiver-operating characteristic curve (AUROC).

Results

Of 142 patients with EUS-SWE spleen measurements, 13 (9.2%) had CSPH and 129 (90.8%) did not. Patients with CSPH had a significantly higher mean spleen stiffness (37.6 ± 8.5 kPA vs 29.1 ± 9.9 kPA, P = .003). The AUROC was .74.