Efficient synthesis of halobenzothioamides from the hydrosulfuration of halobenzonitriles and mechanism investigation

Abstract

An efficient method for the synthesis of various halobenzothioamides from the hydrosulfuration of a variety of halobenzonitriles with NaHS under mild conditions was developed by adding auxiliary reagent MgCl₂ · 6 H₂O. It was found that an excellent yield of benzothioamides is obtained from the hydrosulfuration of halobenzonitrile with inorganic sulfur reagents by adjusting the pH value of the reaction solution. Reaction condition optimization experiments revealed, that high yields of products were obtained in the pH range of 8–10.