Investigating the DNA binding properties of diruthenium complexes incorporating carboxylated chalcone ligands with phenyl, naphthyl or anthryl moieties
Jiaxin Zou , Songyang Zhang , Bo Zhang , Peter P.F. Lee , Rakesh Ganguly , Yong Leng Kelvin Tan
{"title":"Investigating the DNA binding properties of diruthenium complexes incorporating carboxylated chalcone ligands with phenyl, naphthyl or anthryl moieties","authors":"Jiaxin Zou , Songyang Zhang , Bo Zhang , Peter P.F. Lee , Rakesh Ganguly , Yong Leng Kelvin Tan","doi":"10.1016/j.poly.2025.117409","DOIUrl":null,"url":null,"abstract":"<div><div>Sixteen diruthenium sawhorse and cationic complexes with carboxylated chalcone ligands incorporating phenyl, naphthyl and anthryl moieties have been synthesized and characterized. The cationic complexes were found to be more soluble in aqueous medium than the neutral sawhorse compounds. DNA binding studies carried out for the cationic complexes indicate that the presence of the phenyl, naphthyl and anthryl units influenced the selectivity of the complexes towards quadruplex or duplex DNA.</div></div>","PeriodicalId":20278,"journal":{"name":"Polyhedron","volume":"269 ","pages":"Article 117409"},"PeriodicalIF":2.4000,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polyhedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0277538725000233","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Sixteen diruthenium sawhorse and cationic complexes with carboxylated chalcone ligands incorporating phenyl, naphthyl and anthryl moieties have been synthesized and characterized. The cationic complexes were found to be more soluble in aqueous medium than the neutral sawhorse compounds. DNA binding studies carried out for the cationic complexes indicate that the presence of the phenyl, naphthyl and anthryl units influenced the selectivity of the complexes towards quadruplex or duplex DNA.
期刊介绍：
Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry.
Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
