Investigating the DNA binding properties of diruthenium complexes incorporating carboxylated chalcone ligands with phenyl, naphthyl or anthryl moieties
Jiaxin Zou , Songyang Zhang , Bo Zhang , Peter P.F. Lee , Rakesh Ganguly , Yong Leng Kelvin Tan
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引用次数: 0
Abstract
Sixteen diruthenium sawhorse and cationic complexes with carboxylated chalcone ligands incorporating phenyl, naphthyl and anthryl moieties have been synthesized and characterized. The cationic complexes were found to be more soluble in aqueous medium than the neutral sawhorse compounds. DNA binding studies carried out for the cationic complexes indicate that the presence of the phenyl, naphthyl and anthryl units influenced the selectivity of the complexes towards quadruplex or duplex DNA.
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