{"title":"Pharmacokinetic variation","authors":"Alexander T Vidouris, Craig Carroll","doi":"10.1016/j.mpaic.2024.09.010","DOIUrl":null,"url":null,"abstract":"<div><div>Pharmacokinetics is the study of how a drug is handled by the body, including absorption, distribution, metabolism and excretion. Pharmacokinetic variation is variability in the effector site concentration after a standard dose. This means there is potential for dosing to be ineffective for one patient but potentially toxic with increased side effects for another. This article aims to review some of the causes of variation by looking at physiological, pathological and pharmacological factors.</div></div>","PeriodicalId":45856,"journal":{"name":"Anaesthesia and Intensive Care Medicine","volume":"25 12","pages":"Pages 845-849"},"PeriodicalIF":0.2000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaesthesia and Intensive Care Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1472029924002017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pharmacokinetics is the study of how a drug is handled by the body, including absorption, distribution, metabolism and excretion. Pharmacokinetic variation is variability in the effector site concentration after a standard dose. This means there is potential for dosing to be ineffective for one patient but potentially toxic with increased side effects for another. This article aims to review some of the causes of variation by looking at physiological, pathological and pharmacological factors.
期刊介绍：
Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.
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