A proficient MOF-catalyzed multicomponent one-pot synthesis of 1-((benzo[d]thiazol-2-ylamino)(phenyl)methyl)naphthalen-2-ol derivatives with in vitro anti-Alzheimer validation and DFT calculations

Abstract

Nicotinic acid or vit-B₃ has a lot of important biological uses. It can also be presented as Metal-Organic Framework (MOF) with copper which is presented as a catalyst after the physicochemical characterization of its structure and morphological properties by IR, SEM, EDX, TEM, XRD and DFT calculation. 1-((Benzo[d]thiazol-2-ylamino)(phenyl)methyl) naphthalen-2-ol derivatives were successfully prepared by one-pot catalytic synthesis through the reaction between 2-aminobenzothiazole, aromatic aldehyde and 2-naphthol in the presence of Cu/NA-MOF as a catalyst under solvent-free conditions. The prepared products undergo docking and in vitro evaluation as acetylcholine esterase inhibitors (AChE inhibitors) and are compared with Donepezil as a reference Alzheimer’s drug. The data obtained explained that compound 4-((benzo[d]thiazol-2-ylamino)(2-hydroxynaphthalen-1-yl)methyl)phenyl 4-methylbenzoate (4i) gives promising records.