Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone

Abstract

We reported a direct construction of aza-[3.3.1]-bicycles from 2-aminochalcones and hydrazone. Notably, this method formed a potentially biologically active bridged structure containing multiple nitrogen atoms under mild conditions with high yields. This reaction exhibits broad substrate scope and excellent functional group tolerance. This is a new type of benzo fused bridged azaheterocycles, which will be beneficial for further research on this skeleton.