L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension.

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL European Journal of Medical Research Pub Date : 2025-02-04 DOI:10.1186/s40001-025-02342-8

Wei Zhou, Yumeng Shi, Chao Yu, Tao Wang, Lingjuan Zhu, Huihui Bao, Xiaoshu Cheng

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Abstract

Background: Prior research has established that an ankle-brachial index (ABI) ≤ 0.9 is positively correlated with cardiovascular events, including coronary heart disease (CHD). The present study aimed to elucidate the dose-response relationship between ABI and CHD within a hypertensive population.

Methods: We conducted a cross-sectional analysis involving 10,900 hypertensive patients, with CHD as the primary outcome. A generalized additive model (GAM) and fitted smoothing curve were employed to assess linearity and delineate the dose-response association between ABI and CHD.

Results: The cohort had a mean (SD) age of 68.3 (9.25) years, with 5129 (47.06%) being male. CHD was present in 552 (5.06%) participants. The fully adjusted odds ratio (OR) for CHD associated with ABI levels was 0.75 (95%CI 0.33-1.71). An L-shaped relationship between ABI and CHD was identified, with an inflection point at 1.07. Below this threshold, ABI showed a negative correlation with CHD (OR: 0.27; 95%CI 0.08-0.84), whereas above it, the association was not significant (OR: 3.08; 95%CI 0.60-15.80).

Conclusions: In Chinese adults with hypertension, ABI exhibits a nonlinear, L-shaped association with CHD, with the inflection point at 1.07.

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背景：先前的研究表明，踝肱指数（ABI）≤0.9与心血管事件（包括冠心病）呈正相关。本研究旨在阐明高血压人群中 ABI 与冠心病之间的剂量反应关系：我们对 10,900 名高血压患者进行了横断面分析，并将冠心病作为主要结果。采用广义加和模型（GAM）和拟合平滑曲线来评估线性关系，并界定 ABI 与冠心病之间的剂量-反应关系：组群的平均（标清）年龄为 68.3（9.25）岁，其中 5129 人（47.06%）为男性。552人（5.06%）患有冠心病。经完全调整后，与 ABI 水平相关的心脏病几率比（OR）为 0.75（95%CI 0.33-1.71）。ABI 与心脏病之间呈 L 型关系，拐点为 1.07。在该临界点以下，ABI 与心脏病呈负相关（OR：0.27；95%CI 0.08-0.84），而在该临界点以上，两者之间的关系不显著（OR：3.08；95%CI 0.60-15.80）：结论：在中国成人高血压患者中，ABI 与冠心病的关系呈非线性的 L 型，拐点在 1.07。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.