Increased SARS-CoV-2-related hospitalization and mortality in rheumatoid arthritis patients receiving rituximab therapy-a monocentric retrospective study

IF 3.7 2区 医学 Q2 IMMUNOLOGY Journal of Microbiology Immunology and Infection Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI:10.1016/j.jmii.2025.01.004
Chrong-Reen Wang , Chih-Hui Hsu , Wei-Chieh Lin
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Abstract

From 2022 April to 2024 August, retrospective analyses by multivariable logistic regression were conducted in 341 rheumatoid arthritis patients receiving rituximab (RTX), tofacitinib (TOF) or disease-modifying-anti-rheumatic drug (DMARD) alone therapy. Compared to DMARD alone or TOF treatment, RTX therapy had increased adjusted odds ratios of SARS-CoV-2-related hospitalization, pneumonia and mortality.
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接受利妥昔单抗治疗的类风湿性关节炎患者与sars - cov -2相关的住院率和死亡率增加-一项单中心回顾性研究
2022 年 4 月至 2024 年 8 月,研究人员通过多变量逻辑回归对 341 名接受利妥昔单抗(RTX)、托法替尼(TOF)或单独使用疾病修饰抗风湿药(DMARD)治疗的类风湿性关节炎患者进行了回顾性分析。与单纯 DMARD 或 TOF 治疗相比,RTX 治疗增加了与 SARS-CoV-2 相关的住院、肺炎和死亡率的调整后几率比。
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来源期刊
Journal of Microbiology Immunology and Infection
Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
15.90
自引率
5.40%
发文量
159
审稿时长
67 days
期刊介绍: Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.
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