{"title":"Halt aging? — functional HSCs lead the way","authors":"Rebecca T. Chu, Adam B. Schroer, Saul A. Villeda","doi":"10.1038/s41422-025-01079-7","DOIUrl":null,"url":null,"abstract":"<p><b>The aged immune system contributes to systemic aging, serving as a driver of morbidity and mortality in the elderly. In a recent</b> <b><i>Cell Research</i></b> <b>paper, Wang et al. identified both resilient and dysfunctional subsets of old hematopoietic stem cells (HSCs), of which selective reduction of dysfunctional old HSCs ameliorates aging phenotypes and extends lifespan in mice</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"62 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-025-01079-7","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The aged immune system contributes to systemic aging, serving as a driver of morbidity and mortality in the elderly. In a recentCell Researchpaper, Wang et al. identified both resilient and dysfunctional subsets of old hematopoietic stem cells (HSCs), of which selective reduction of dysfunctional old HSCs ameliorates aging phenotypes and extends lifespan in mice.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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