The Combined Empagliflozin and Sacubitril/Valsartan Therapy Attenuates Isoproterenol-Induced Heart Failure in Rats: Functional, Molecular, and Structural Insights.

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Drugs and Therapy Pub Date : 2026-02-01 Epub Date: 2025-02-06 DOI:10.1007/s10557-025-07675-4

Maja Muric, Ivan Srejovic, Jovana Novakovic, Vladimir Zivkovic, Jovana Joksimovic Jovic, Jasmina Sretenovic, Marina Nikolic, Nevena Lazarevic, Marijana Andjic, Aleksandar Kocovic, Jovana Jakovljevic Uzelac, Sergey Bolevich, Vladimir Jakovljevic

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Abstract

Purpose: The idea behind this study was to assess the effects of empagliflozin and sacubitril/valsartan and their combination on isoproterenol-induced heart failure (HF) and underlying molecular mechanisms.

Methods: HF was induced with 7-day isoproterenol (5 mg/kg daily), confirmed by ejection fraction below 55% after 4 weeks. HF rats received empagliflozin, sacubitril/valsartan, or both for 4 weeks. Parameters measured included hemodynamics, cardiac function, redox status, and histomorphology.

Results: Isoproterenol impaired hemodynamics and cardiac function, increased oxidative damage, and altered cardiac structure. All treatments were cardioprotective; however, combined empagliflozin and sacubitril/valsartan therapy had the most pronounced effect.

Conclusion: Combined empagliflozin and sacubitril/valsartan showed superior cardioprotection in HF, primarily by enhancing antioxidative effects. These findings support early use of both drugs in HF treatment.

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恩格列净联合苏比利/缬沙坦治疗减轻异丙肾上腺素诱导的大鼠心力衰竭：功能、分子和结构观察

目的：本研究的目的是评估恩格列净和苏比里尔/缬沙坦及其联合用药对异丙肾上腺素诱导的心力衰竭（HF）的影响及其潜在的分子机制。方法：用异丙肾上腺素（5mg /kg / d）诱导HF 7 d， 4周后射血分数低于55%。HF大鼠接受恩格列净、苏比里尔/缬沙坦或两种治疗4周。测量的参数包括血流动力学、心功能、氧化还原状态和组织形态学。结果：异丙肾上腺素损害了血液动力学和心功能，增加了氧化损伤，改变了心脏结构。所有治疗均具有心脏保护作用；然而，联合恩格列净和苏比里尔/缬沙坦治疗效果最显著。结论：恩格列净联合苏比里尔/缬沙坦对心力衰竭有较好的心脏保护作用，主要是通过增强抗氧化作用。这些发现支持在心衰治疗中早期使用这两种药物。

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来源期刊

Cardiovascular Drugs and Therapy 医学-心血管系统

CiteScore

8.30

自引率

0.00%

发文量

110

审稿时长

4.5 months

期刊介绍： Designed to objectively cover the process of bench to bedside development of cardiovascular drug, device and cell therapy, and to bring you the information you need most in a timely and useful format, Cardiovascular Drugs and Therapy takes a fresh and energetic look at advances in this dynamic field. Homing in on the most exciting work being done on new therapeutic agents, Cardiovascular Drugs and Therapy focusses on developments in atherosclerosis, hyperlipidemia, diabetes, ischemic syndromes and arrhythmias. The Journal is an authoritative source of current and relevant information that is indispensable for basic and clinical investigators aiming for novel, breakthrough research as well as for cardiologists seeking to best serve their patients. Providing you with a single, concise reference tool acknowledged to be among the finest in the world, Cardiovascular Drugs and Therapy is listed in Web of Science and PubMed/Medline among other abstracting and indexing services. The regular articles and frequent special topical issues equip you with an up-to-date source defined by the need for accurate information on an ever-evolving field. Cardiovascular Drugs and Therapy is a careful and accurate guide through the maze of new products and therapies which furnishes you with the details on cardiovascular pharmacology that you will refer to time and time again.