Prenatal stress effects on the placenta

IF 20 1区 医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2025-02-06 DOI:10.1038/s41593-025-01887-5
Laura Zelenka
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产前压力对胎盘的影响
母亲压力已被确定为影响后代世代长期健康的关键因素。King等人最近发表在《通讯生物学》(Communications Biology)杂志上的一项研究描述了产前母亲压力对胎盘和胎儿皮质样本中DNA甲基化和基因表达的影响,这些样本跨越了四代(F0-F3)。在表观遗传编程的关键时期(胚胎期12-18天)暴露于产前母亲压力导致F2和F3代的累积变化,这种变化比F1代更为明显。跨代编程主要确定了与神经和精神疾病相关的基因和生物学途径,这些疾病与胎盘介导的母胎相互作用有关。这项研究增强了我们对产前母亲压力引起的发育变化的分子机制的理解,并表明胎盘是神经发育健康预测性生物标志物的潜在来源。原始参考文献:common。生物学报,8,38 (2025)
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来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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