Comment on “The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry”
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引用次数: 0
Abstract
This study in Oral Oncology highlights how neoadjuvant immunotherapy reshapes the tumor immune microenvironment (TIME) in HNSCC, increasing CD8+ T cells and reducing immunosuppressive cells. Using multiplex immunohistochemistry, it offers crucial spatial insights into TIME dynamics, paving the way for biomarker development and personalized therapies. Future research should explore combining this approach with single-cell technologies to elucidate functional immune states, enhancing our understanding of therapeutic responses and informing novel combinatorial treatment strategies.
期刊介绍：
Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck.
Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.
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