Rapid and sensitive determination of sildenafil citrate by adsorption stripping voltammetry using a solid lead microelectrode

IF 4.1 3区化学 Q1 CHEMISTRY, ANALYTICAL Journal of Electroanalytical Chemistry Pub Date : 2025-02-07 DOI:10.1016/j.jelechem.2025.119000

Mateusz Ochab

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引用次数: 0

Abstract

A solid state lead microelectrode (PbµE), was used for the rapid and sensitive determination of sildenafil citrate (SC) in pharmaceutical formulations by the stripping method. The method involves the accumulation of SC on a solid lead microelectrode with diameter of 25 µm, by an adsorption process. In the stripping step, two well-formed reduction peaks at −1.22 (P₁) and −1.31 V (P₂) were obtained during SC reduction. The calibration curve of SC for 180 s accumulation time was linear in the range from 5 × 10⁻¹⁰ to 2 × 10⁻⁸ mol/L for P₁ and P₂, while the detection limit was 1.8 × 10⁻¹⁰ and 2.4 × 10⁻¹⁰ mol/L, respectively. The solid lead microelectrode demonstrated good repeatability (RSD 4,2% for n = 10), durability for a long period of time and its more eco-friendly as compared to lead film electrodes. The procedure was successfully applied to the determination of SC in a pharmaceutical formulations.

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来源期刊

Journal of Electroanalytical Chemistry 化学-电化学

CiteScore

7.80

自引率

6.70%

发文量

912

审稿时长

2.4 months

期刊介绍： The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.