{"title":"Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice.","authors":"N A Beregovoy, G K Volcho, M V Starostina","doi":"10.1007/s10517-025-06323-z","DOIUrl":null,"url":null,"abstract":"<p><p>The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"291-294"},"PeriodicalIF":0.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06323-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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