Malignant fibrous histiocytoma of the mandible: A rare case report with diagnostic challenge and treatment approach.

Q3 Medicine Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI:10.4103/jomfp.jomfp_98_24
Preethi N Sharma, Minal S Chaudhary, Alka H Hande, Swati K Patil
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Abstract

Malignant fibrous histiocytoma (MFH), now termed undifferentiated pleomorphic sarcoma (UPS), is a high-grade tumour, mostly affecting the extremities and retroperitoneum. It is a rare entity in the mandible. After a literature search in the PubMed database, only 15 cases have been reported, indicating how uncommon it is in the mandible. In this instance, we document an unusual occurrence of MFH, affecting the mandible in a 37-year-old male patient. Histopathology of the biopsy specimen along with the strong positivity to immunohistochemical markers such as Vimentin and CD68 confirmed the diagnosis of MFH. It is a rare entity presenting diagnostic and therapeutic challenges requiring a multidisciplinary approach for optimal management and treatment.

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下颌骨恶性纤维组织细胞瘤:罕见病例报告及诊断难题和治疗方法。
恶性纤维组织细胞瘤(MFH),现称为未分化多形性肉瘤(UPS),是一种高级别肿瘤,主要累及四肢和腹膜后。这是一个罕见的实体在下颌骨。在PubMed数据库中进行文献检索后,只有15例被报道,这表明它在下颌骨中是多么罕见。在这个例子中,我们记录了一个不寻常的MFH的发生,影响了一个37岁的男性患者的下颌骨。活检标本的组织病理学及免疫组织化学标志物如Vimentin、CD68阳性,证实MFH的诊断。它是一种罕见的实体呈现诊断和治疗的挑战,需要多学科的方法来优化管理和治疗。
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来源期刊
Journal of Oral and Maxillofacial Pathology
Journal of Oral and Maxillofacial Pathology Medicine-Otorhinolaryngology
CiteScore
1.40
自引率
0.00%
发文量
115
期刊介绍: The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.
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