{"title":"Connecting the structure and function of cartilage using spatial ‘-omics’","authors":"Indira Prasadam, Xiwei Fan","doi":"10.1038/s41584-025-01225-w","DOIUrl":null,"url":null,"abstract":"Advances in spatial ‘-omics’, such as transcriptomics and proteomics, have provided vital insights into cartilage microenvironments, revealing cellular diversity, zonal organization and links between cartilage structure and function. Analysing cartilage using spatial ‘-omics’ could deepen the understanding of diseases such as osteoarthritis and guide the development of targeted, disease-modifying therapies.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"30 1","pages":""},"PeriodicalIF":29.4000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41584-025-01225-w","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Advances in spatial ‘-omics’, such as transcriptomics and proteomics, have provided vital insights into cartilage microenvironments, revealing cellular diversity, zonal organization and links between cartilage structure and function. Analysing cartilage using spatial ‘-omics’ could deepen the understanding of diseases such as osteoarthritis and guide the development of targeted, disease-modifying therapies.
期刊介绍：
Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.
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