Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N′Djamena: Insights Into Chad's COVID-19 Epicenter

IF 4.6 3区医学 Q1 VIROLOGY Journal of Medical Virology Pub Date : 2025-02-18 DOI:10.1002/jmv.70234

Mathiew Hota, Andrillene L. D. Wondeu, Mahamat F. Abakar, Koutaya Dezoumbe, Fatima Abdelrazakh, Sabrina Atturo, Nathan Naïbeï, Giulia Cappelli, Franck Mennechet, Fissou H. Yandai, Djamal H. Abdallah, Zongo R. F. Edgard, Abdoulaye Boukar, Choroma A. Moussa, Issa M. Yaya, Mahamat I. Hamad, Nontegyol Armand, Netalar Honorine, Kayanlengar Frederic, Adam A. Moustapha, Yanda M. Daniel, Adam M. Alim, Mahamat Grene, Oumaima Djarma, Noubaramadji Y. Suitombaye, Amine Akouya, Ouchemi Choua, Guy R. T. Dzomo, Djallaye Djimtoïbaye, Vittorio Colizzi, Mahamat A. Moussa, Marta Giovanetti

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Abstract

The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.

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对 N′Djamena 的 SARS-CoV-2 病毒株进行血清流行率和基于基因组的综合研究：洞察乍得的 COVID-19 中心

COVID-19疫情在传播和结果方面显示出区域差异。作为乍得的主要热点，恩贾梅纳对全面流行病学调查至关重要。本研究采用两种方法：血清阳性率数据收集和SARS-CoV-2株全基因组测序。这种双重方法评估了人群暴露和病毒遗传多样性。血清阳性率数据表明，暴露范围比确诊病例所显示的更广，基因组测序确定了多种菌株，包括全球公认的令人担忧的变体。整合这些数据可以深入了解传播动态、潜在的群体免疫阈值以及特定变异对疾病进展的影响。我们的研究结果强调了传染病流行病学综合多学科研究的重要性，并为有针对性的公共卫生战略提供信息，包括社会措施和疫苗接种，以在恩贾梅纳防治传染病。

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.