Fluoride exposure and its interaction with ATP2B1 polymorphism in the alteration of lipid metabolism in adults.

IF 1.9 4区医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2025-10-01 Epub Date: 2025-02-18 DOI:10.1080/09603123.2025.2466674

Junhua Wu, Ming Qin, Yue Gao, Yang Liu, Xiaona Liu, Yuting Jiang, Yanmei Yang, Yanhui Gao

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Abstract

Previous studies found relationship between fluoride exposure and lipid metabolism. In present study, a cross-sectional study was conducted. Urinary fluoride concentrations and lipid metabolism indicators were tested. Single nucleotide polymorphisms of ATP2B1 were sequenced. The median of urinary fluoride was 1.32 mg/L. Urinary fluoride was positively associated with the decrease in serum ApoA1 (OR = 1.48 [95% CI, 1.27-1.72]), inversely with ApoB elevation (OR = 0.69 [95% CI, 0.59-0.80]). Rs12817819 with carriers of T allele was associated with the decrease in serum ApoA1 (OR = 0.46 [95% CI, 0.26-0.81]), but inversely in rs17249754 with carriers for A allele (OR = 1.48 [95% CI, 1.07-2.06]) and rs7136259 with carriers for T allele (OR = 1.70 [95% CI, 1.22-2.37]). There was an interaction between urinary fluoride which was lower than 0.9 mg/L and rs7136259 for carriers of T allele (OR = 2.67 [95% CI, 1.34-5.31]) in serum ApoA1 decrease. It indicated fluoride exposure might be associated with the alteration of serum ApoA1 and ApoB in adults.

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氟暴露及其与ATP2B1多态性在成人脂质代谢改变中的相互作用

先前的研究发现氟化物暴露与脂质代谢之间存在关系。本研究采用横断面研究。检测尿氟浓度和脂质代谢指标。对ATP2B1的单核苷酸多态性进行测序。尿氟化物中位数为1.32 mg/L。尿氟化物与血清ApoA1降低呈正相关（OR = 1.48 [95% CI, 1.27-1.72]），与ApoB升高呈负相关（OR = 0.69 [95% CI, 0.59-0.80]）。携带T等位基因的Rs12817819与血清ApoA1下降相关（OR = 0.46 [95% CI, 0.26-0.81]），携带A等位基因的rs17249754与携带T等位基因的rs7136259呈负相关（OR = 1.48 [95% CI, 1.07-2.06]），携带T等位基因的rs7136259与血清ApoA1下降相关（OR = 1.70 [95% CI, 1.22-2.37]）。T等位基因携带者尿氟化物低于0.9 mg/L与rs7136259之间存在交互作用（OR = 2.67 [95% CI, 1.34-5.31]）。提示氟暴露可能与成人血清ApoA1和ApoB的改变有关。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.