[Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing].

Yue Li, Xiao-Hui Zhou, Xiao-Dong Wang, Chun-Jing Wang, Ke Cao, Si-Xi Liu
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Abstract

This article reports the clinical characteristics and treatment processes of three cases of mucormycosis occurring after hematopoietic stem cell transplantation in children, along with a review of relevant literature. All three patients presented with chest pain as the initial symptom, and metagenomic next-generation sequencing (mNGS) confirmed the mucycete infection early in all cases. Two patients recovered after treatment, while one succumbed to disseminated infection. mNGS has facilitated early diagnosis and treatment, reducing mortality rates. Additionally, surgical intervention is an important strategy for improving the prognosis of this condition.

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[3例儿童造血干细胞移植后毛霉菌病的宏基因组新一代测序诊断]。
本文报道3例儿童造血干细胞移植后发生毛霉菌病的临床特点及治疗过程,并对相关文献进行复习。所有3例患者均以胸痛为初始症状,宏基因组新一代测序(mNGS)在所有病例中早期证实了黏液菌感染。两名病人经治疗后痊愈,一名病人死于播散性感染。mNGS促进了早期诊断和治疗,降低了死亡率。此外,手术干预是改善这种疾病预后的重要策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
中国当代儿科杂志
中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.50
自引率
0.00%
发文量
5006
期刊介绍: The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R;ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.
期刊最新文献
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