{"title":"Same but different: Centromere regulations in holocentric insects and plants","authors":"André Marques , Ines A. Drinnenberg","doi":"10.1016/j.ceb.2025.102484","DOIUrl":null,"url":null,"abstract":"<div><div>Centromeres are essential chromosomal regions responsible for ensuring proper chromosome segregation during cell division. Unlike monocentric chromosomes, which have a single centromeric region, holocentric chromosomes distribute centromeric activity along their entire length. This unique organization poses intriguing questions about its structure, function, and evolutionary origins. In this review, we outline recent advances in characterizing the molecular architectures of holocentric chromosomes in mitosis and meiosis, emphasizing both the shared features and lineage-specific adaptations that have evolved in plants and insects. A more detailed characterization of holocentric architectures across different lineages will also offer valuable insights into the potential mechanisms driving the evolutionary transition from monocentric to holocentric chromosomes.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"93 ","pages":"Article 102484"},"PeriodicalIF":6.0000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955067425000225","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Centromeres are essential chromosomal regions responsible for ensuring proper chromosome segregation during cell division. Unlike monocentric chromosomes, which have a single centromeric region, holocentric chromosomes distribute centromeric activity along their entire length. This unique organization poses intriguing questions about its structure, function, and evolutionary origins. In this review, we outline recent advances in characterizing the molecular architectures of holocentric chromosomes in mitosis and meiosis, emphasizing both the shared features and lineage-specific adaptations that have evolved in plants and insects. A more detailed characterization of holocentric architectures across different lineages will also offer valuable insights into the potential mechanisms driving the evolutionary transition from monocentric to holocentric chromosomes.
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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