Organosilane Functionalized Graphene Oxide Nanocomposite as Fluorescent Chemosensor for the Detection of Tyrosine in Aqueous Medium

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED Applied Organometallic Chemistry Pub Date : 2025-02-20 DOI:10.1002/aoc.70081

Gurjaspreet Singh, Swati Devi, Akshpreet Singh, Samiksha Sharma, Devina Sharma, Pallavi Markan, Harshbir Kaur, Necmi Dege, Seher Meral

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Abstract

In the present article, a selective and efficient sensor based on organosilane functionalized graphene oxide nanocomposites has been synthesized for the fluorometric detection of tyrosine (Tyr). The 1,2,3-triazole functionalized organosilane has been synthesized by a condensation reaction between 4-(methylthio) aniline and alkylated benzaldehyde followed by azide-alkyne cycloaddition reaction using Cu (I) catalyst. The synthesized organosilane has been fabricated on graphene oxide nanoparticles and the obtained graphene-functionalized organosilane (GO-Silane) was characterized by FTIR and XRD. The morphology of the nanocomposite film was analyzed using scanning electron microscopy. The photophysical properties of GO-Silane were studied which established its selective sensor for tyrosine with the limit of detection values of 1.04 × 10⁻⁸ M with a response time of 8 s. The strong coordinated interactions of GO-Silane for the Tyr have been confirmed from FTIR spectra of the GO-Silane-Tyr complex. The competitive amino acid interference assay successfully demonstrated the selectivity of the nanocomposite sensor.

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有机硅烷功能化氧化石墨烯纳米复合材料检测水中酪氨酸的荧光化学传感器

本文合成了一种基于有机硅烷功能化氧化石墨烯纳米复合材料的选择性高效传感器，用于荧光检测酪氨酸（Tyr）。采用4-（甲基硫）苯胺与烷基化苯甲醛缩合反应，再以Cu (I)为催化剂进行叠氮-炔环加成反应，合成了1,2,3-三唑功能化有机硅烷。在氧化石墨烯纳米颗粒上制备了合成的有机硅烷，并用FTIR和XRD对得到的石墨烯功能化有机硅烷（go -硅烷）进行了表征。利用扫描电镜对纳米复合膜的形貌进行了分析。研究了氧化石墨烯硅烷的光物理性质，建立了酪氨酸选择性传感器，检测限为1.04 × 10−8 M，响应时间为8 s。氧化石墨烯-硅烷-Tyr配合物的红外光谱证实了氧化石墨烯-硅烷对Tyr的强协同相互作用。竞争性氨基酸干扰实验成功地证明了纳米复合传感器的选择性。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.