Flecainide Intoxication: An Unusual Case of Suicide.

IF 0.8 4区 医学 Q3 MEDICINE, LEGAL American Journal of Forensic Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-02-24 DOI:10.1097/PAF.0000000000001026
Shumin Fan, Keith Norman Norton
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Abstract

Abstract: Flecainide is among the most prescribed antiarrhythmic medications and is used to effectively treat recurrent arrhythmia and maintain normal sinus rhythm by acting as a sodium channel blocker. However, its potent effects and narrow therapeutic window pose increasing risks of flecainide intoxication and ensuing morbidity and mortality. Here we report an unusual case of suicide by intentional flecainide overdose. This case demonstrates the importance of early recognition and treatment in avoiding the adverse consequences of flecainide intoxication, and it also demonstrates the importance of appropriate use and safe storage of flecainide.

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弗莱卡因中毒:一个不寻常的自杀案例。
摘要:氟卡因胺是常用的抗心律失常药物之一,可作为钠通道阻滞剂有效治疗复发性心律失常,维持正常的窦性心律。然而,其强大的作用和狭窄的治疗窗口增加了氟氯胺中毒和随之而来的发病率和死亡率的风险。在这里,我们报告了一个不寻常的自杀案件故意氟氯胺过量。该病例表明早期识别和治疗对于避免氟氯胺中毒的不良后果的重要性,也表明了适当使用和安全储存氟氯胺的重要性。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
103
审稿时长
4-8 weeks
期刊介绍: Drawing on the expertise of leading forensic pathologists, lawyers, and criminologists, The American Journal of Forensic Medicine and Pathology presents up-to-date coverage of forensic medical practices worldwide. Each issue of the journal features original articles on new examination and documentation procedures. While most articles are available as web based articles, PDF and in ePub reader format, some earlier articles do not have PDFs available. If you would like to view an article in the ePub format, you will need to download an ePub reader to view this file, a number of which are available for free online.
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