Hemolysis Biomarkers After Pulmonary Vein Isolation via a Balloon-In-Basket PFA Catheter

IF 2.6 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Electrophysiology Pub Date : 2025-02-20 DOI:10.1111/jce.16608

Lorenzo Marcon, Domenico G. Della Rocca, Giampaolo Vetta, Kazutaka Nakasone, Antonio Sorgente, Carlo de Asmundis, Gian-Battista Chierchia

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Abstract

Introduction

The extensive use of pulsed field ablation (PFA) in clinical settings has unveiled new evidence suggesting potential involvement in red blood cell structural impairment resulting in hemolysis and potential acute kidney injury (AKI).

Methods

In this study, blood samples were collected from 16 patients before and 24 h after pulmonary vein isolation (PVI) via a novel investigational PFA-based technology. Biochemical analyses were performed to assess hemolysis and AKI, including total and indirect bilirubin, lactate dehydrogenase (LDH), haptoglobin, plasma free hemoglobin, urea, creatinine, and estimated glomerular filtration rate (eGFR).

Results

Based on the periprocedural changes in hemolysis biomarkers, none of the patients displayed evidence of clinically relevant hemolysis following PVI with the PFA catheter.

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球囊内PFA导管肺静脉隔离后的溶血生物标志物。

简介：脉冲场消融（PFA）在临床环境中的广泛应用揭示了新的证据，表明其可能参与红细胞结构损伤，导致溶血和潜在的急性肾损伤（AKI）。方法：在本研究中，通过一种新的基于肺静脉分离（pfa）的研究性技术，采集了16例患者在肺静脉分离（PVI）前和24 h后的血液样本。进行生化分析以评估溶血和AKI，包括总胆红素和间接胆红素、乳酸脱氢酶（LDH）、触珠蛋白、血浆游离血红蛋白、尿素、肌酐和估计的肾小球滤过率（eGFR）。结果：根据溶血生物标志物的围手术期变化，没有患者在PFA导管PVI后出现临床相关的溶血证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Electrophysiology 医学-心血管系统

CiteScore

5.20

自引率

14.80%

发文量

433

审稿时长

3-6 weeks

期刊介绍： Journal of Cardiovascular Electrophysiology (JCE) keeps its readership well informed of the latest developments in the study and management of arrhythmic disorders. Edited by Bradley P. Knight, M.D., and a distinguished international editorial board, JCE is the leading journal devoted to the study of the electrophysiology of the heart.