Association Between Vitamin D Receptor BsmI Polymorphism and Low Bone Mineral Density in Postmenopausal Women in the MENA Region.

IF 2.7 Q2 PATHOLOGY Pathophysiology Pub Date : 2025-02-01 DOI:10.3390/pathophysiology32010006

Tara Al-Barazenji, Asma Allouch, Nedhal Al Husaini, Sondos Yousef, Wisam Nabeel Ibrahim, Amal Al-Haidose, Hatem Zayed, Atiyeh M Abdallah

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Abstract

Background/objectives: Low bone mineral density increases the risk of bone fractures, and this condition is especially common in postmenopausal women. Genetic factors significantly influence bone mineral density. This meta-analysis examined the relationship between vitamin D receptor (VDR) gene polymorphisms (BsmI, ApaI, and TaqI) and bone mineral density in postmenopausal women in the Middle East and North Africa (MENA) region.

Methods: The PubMed, Embase, Scopus, and Web of Science databases were searched from inception to March 2024 for case-control studies on VDR BsmI, ApaI, and TaqI polymorphisms and their relationship with low bone density. Associations with low bone mineral density were tested with respect to different genetic models (dominant, recessive, allelic) using RevMan v5.3.

Results: The meta-analysis included seven studies for BsmI, six for ApaI, and seven for TaqI, representing 704/689 cases/controls for BsmI, 914/711 for ApaI, and 974/895 for TaqI. No significant association was found between VDR polymorphisms and low bone mineral density in postmenopausal women, except in the dominant model (CC + CG vs. GG) for the BsmI variant (OR = 1.27, 95% CI: 1.01-1.59, p = 0.04).

Conclusions: We found a modest association between the BsmI polymorphism and increased risk of low bone mineral density (BMD) in postmenopausal women from the MENA region, suggesting its potential as a biomarker. No associations were observed for ApaI or TaqI. These findings highlight the complex genetic-environmental interactions influencing BMD.

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背景/目的：骨矿物质密度低会增加骨折风险，这种情况在绝经后妇女中尤为常见。遗传因素对骨矿物质密度有重大影响。这项荟萃分析研究了中东和北非地区绝经后妇女维生素 D 受体（VDR）基因多态性（BsmI、ApaI 和 TaqI）与骨矿物质密度之间的关系：方法：检索了 PubMed、Embase、Scopus 和 Web of Science 数据库中从开始到 2024 年 3 月有关 VDR BsmI、ApaI 和 TaqI 多态性及其与低骨密度关系的病例对照研究。使用 RevMan v5.3 测试了不同遗传模型（显性、隐性、等位基因）与低骨密度的关系：荟萃分析包括针对 BsmI 的 7 项研究、针对 ApaI 的 6 项研究和针对 TaqI 的 7 项研究，分别代表 BsmI 的 704/689 个病例/对照、ApaI 的 914/711 个病例/对照和 TaqI 的 974/895 个病例/对照。除 BsmI 变体的显性模型（CC + CG vs. GG）（OR = 1.27，95% CI：1.01-1.59，p = 0.04）外，未发现 VDR 多态性与绝经后妇女骨矿物质密度低之间有明显关联：我们发现，BsmI 多态性与中东和北非地区绝经后妇女骨矿物质密度（BMD）偏低的风险增加有一定关系，这表明它有可能成为一种生物标志物。ApaI和TaqI多态性之间没有关联。这些发现凸显了遗传与环境之间影响 BMD 的复杂相互作用。

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来源期刊

Pathophysiology Medicine-Pathology and Forensic Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.