{"title":"Pathophysiology-Directed Engineering of a Combination Nanoanalgesic for Neuropathic Pain (Adv. Sci. 8/2025)","authors":"Wenkai Wang, Yan Wang, Xinle Huang, Peng Wu, Lanlan Li, Yang Zhang, Yihui Chen, Zhiyu Chen, Changqing Li, Yue Zhou, Jianxiang Zhang","doi":"10.1002/advs.202570047","DOIUrl":null,"url":null,"abstract":"<p><b>Combination Nanoanalgesic for Neuropathic Pain</b></p><p>In article number 2405483, Yue Zhou, Jianxiang Zhang, and co-workers report a combination nanoanalgesic composed of inflammation-resolving nanomicelles and an analgesic peptide targeting the calcium channel α2δ1 subunit. This innovative nanotherapy effectively inhibits neuroinflammation, promotes nerve regeneration, and provides analgesic activity, thereby affording synergistic effects for the treatment of neuropathic pain induced by nerve injury.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 8","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570047","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570047","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Combination Nanoanalgesic for Neuropathic Pain
In article number 2405483, Yue Zhou, Jianxiang Zhang, and co-workers report a combination nanoanalgesic composed of inflammation-resolving nanomicelles and an analgesic peptide targeting the calcium channel α2δ1 subunit. This innovative nanotherapy effectively inhibits neuroinflammation, promotes nerve regeneration, and provides analgesic activity, thereby affording synergistic effects for the treatment of neuropathic pain induced by nerve injury.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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