Diphtheria Outbreak among Persons Experiencing Homelessness, 2023, Linked to 2022 Diphtheria Outbreak, Frankfurt am Main, Germany

IF 7.2 2区医学 Q1 IMMUNOLOGY Emerging Infectious Diseases Pub Date : 2025-02-24 DOI:10.3201/eid3103.241217

Jonas Haller, Anja Berger, Alexandra Dangel, Katja Bengs, Imke Friedrichs, Christian Kleine, Dorothee Schmidt, Maria Goetzens, Udo Goetsch, Michael Hogardt, Andreas Sing

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Abstract

After 3 cases of Corynebacterium diphtheriae infection associated with intravenous drug use among persons experiencing homelessness (PEH) were reported to the Health Protection Authority in Frankfurt am Main, Germany, in 2023, we examined pathogen spread among PEH. Furthermore, we investigated a possible link with the 2022 outbreak of diphtheria in Europe. From swab samples collected during August–November 2023 from 36 PEH and cutaneous lesions, we detected 3 additional cases of cutaneous toxigenic C. diphtheriae. Sequence type 574 was identified in 5 case-isolates and is genetically associated with 1 of the predominant clusters in identified in the 2022 outbreak. Our findings demonstrate the need for increased detection and monitoring of cutaneous diphtheria and boosting immunity against diphtheria in groups with increased risk for infection. Genomic analyses are valuable for identifying genetic relationships between outbreaks, even when epidemiologic data are scarce.

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2023 年，德国美因河畔法兰克福卫生防护局接报了 3 例无家可归者（PEH）因静脉注射毒品而感染白喉杆菌的病例，之后我们对病原体在无家可归者中的传播情况进行了研究。此外，我们还调查了与 2022 年欧洲爆发的白喉疫情可能存在的联系。从 2023 年 8 月至 11 月期间收集的 36 例 PEH 和皮肤病变的拭子样本中，我们又发现了 3 例皮肤毒性白喉杆菌病例。在 5 个病例分离样本中发现了序列类型 574，该序列类型与 2022 年疫情中发现的 1 个主要簇群存在遗传关联。我们的研究结果表明，有必要加强对皮肤白喉的检测和监测，并提高感染风险较高人群对白喉的免疫力。即使在流行病学数据匮乏的情况下，基因组分析对于确定疫情之间的遗传关系也很有价值。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.