Asep Rizaludin, Isa Mahendra, Muhamad Basit Febrian, Ahmad Kurniawan, Basril Abbas, Yessy Warastuti, Army Adi Sutanningsih, Wira Y. Rahman, Fajar Lukitowati, Arie Hardian
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引用次数: 0
Abstract
Radiosynovectomy is a treatment for patients with rheumatoid arthritis (RA) that affects joints by injecting beta-emitting radiopharmaceuticals into the synovial membrane of inflamed joints. In this study, we established 32Phosphorus labelled hydroxyapatite (32P-HAp) using gamma-irradiated hydroxyapatite material from bovine. Our results showed that gamma-irradiation of bovine HAp tends to agglomerate the particle and form a micro-sized HAp. In addition, irradiated HAp exhibited Ca/P ratio higher than non-irradiated HAp. The ex-vivo biodistribution studies exhibited a high accumulation of irradiated 32P-HAp in the inflamed joints, resulting in good therapeutic effectiveness. Our study demonstrated the potential of 32P-HAp from irradiated bovine hydroxyapatite for radiosynovectomy therapy.
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An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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