Harnessing the potential of nanoprisms for diagnostic and therapeutic applications

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL Colloid and Interface Science Communications Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI:10.1016/j.colcom.2025.100826

Radhika Joshi , Swapnil Sharma , Nemat Ali , Ghazala Muteeb , Mohammad Fareed , Prawez Alam , Devesh U. Kapoor , Bhupendra G. Prajapati

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Abstract

Nanoprisms, a distinctive class of nanostructures, have garnered significant attention in nanomedicine due to their exceptional optical, electronic, and physicochemical properties. This review highlights the diagnostic and therapeutic potential of nanoprisms, emphasizing their transformative role in modern healthcare. First, it provides an overview of current diagnostic and therapeutic strategies within nanomedicine and underscores the unique attributes of nanoprisms. The synthesis and functionalization of nanoprisms, including seed-mediated growth and surface modification techniques like PEGylation and ligand conjugation, are discussed, showcasing how size, shape, and material composition influence their applications. Their diagnostic capabilities span bioimaging techniques, such as plasmonic and photoacoustic imaging, molecular diagnostics, and pathogen detection. In therapeutics, nanoprisms excel in photothermal cancer therapy, targeted drug delivery, and antimicrobial applications, including combating multidrug-resistant strains. Finally, the review addresses existing challenges and future opportunities in advancing nanoprism-based technologies, paving the way for innovative solutions in diagnostics and therapy.

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利用纳米棱镜在诊断和治疗方面的应用潜力

纳米棱镜是一种独特的纳米结构，由于其独特的光学、电子和物理化学性质，在纳米医学中引起了极大的关注。这篇综述强调了纳米棱镜的诊断和治疗潜力，强调了它们在现代医疗保健中的变革作用。首先，它概述了纳米医学中当前的诊断和治疗策略，并强调了纳米棱镜的独特属性。讨论了纳米棱镜的合成和功能化，包括种子介导的生长和表面修饰技术，如聚乙二醇化和配体偶联，展示了尺寸，形状和材料组成如何影响其应用。他们的诊断能力跨越生物成像技术，如等离子体和光声成像、分子诊断和病原体检测。在治疗方面，纳米棱镜在光热癌症治疗、靶向给药和抗微生物应用（包括对抗多重耐药菌株）方面表现出色。最后，该综述指出了推进纳米棱镜技术的现有挑战和未来机遇，为诊断和治疗的创新解决方案铺平了道路。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.