{"title":"Restoring the primary cilia–autophagy axis in neurons to foster cognitive resilience","authors":"","doi":"10.1038/s43587-025-00834-0","DOIUrl":null,"url":null,"abstract":"By exploring how bloodborne factors (such as osteocalcin) help to counteract age-related cognitive decline, we identified a primary cilium–autophagy axis that regulates neuronal homeostasis and cognitive resilience. Osteocalcin promotes neuronal autophagy through its receptor GPR158 at the primary cilium; restoring this pathway in aged mice improves age-related cognitive deficits.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"348-349"},"PeriodicalIF":19.4000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00834-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
By exploring how bloodborne factors (such as osteocalcin) help to counteract age-related cognitive decline, we identified a primary cilium–autophagy axis that regulates neuronal homeostasis and cognitive resilience. Osteocalcin promotes neuronal autophagy through its receptor GPR158 at the primary cilium; restoring this pathway in aged mice improves age-related cognitive deficits.
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